The data, however, also show considerable heterogeneity in CV risk and differences in risk categorisation between the STENO tool and ESC criteria.There is a need for refinement of CV risk classification in T1D, and future studies should investigate if evaluation of arterial stiffness should be implemented in T1D clinical practice and which patients benefit the most from its assessment.Ītherosclerotic cardiovascular disease (CVD) is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Cf-PWV strongly associates with the STENO risk score for future CV events and with cardiovascular imaging and function outcomes, thereby illustrating the clinical importance of arterial stiffness. This study demonstrated that a substantial proportion of long-standing T1D patients free from known CVD show premature arterial stiffening. Cf-PWV was strongly associated with the STENO score (rs = + 0.81 R2 = 0.566, p 10% 10-year risk for CV events (n = 44/54 81.5% versus n = 34/54 63%). Based on STENO, 20 patients (37%) were at low, 20 patients (37%) at moderate, and 14 patients (26%) at high 10-year risk for CV event. Cf-PWV was significantly associated with CAC score, carotid intima-media thickness, central hemodynamic parameters and diabetic kidney disease. One-fourth of patients showed prematurely increased aortic stiffness based on cf-PWV (24%). Data on renal function and diabetic kidney disease was retrieved.ĥ4 patients (age: 46 ± 9.5 years T1D duration: 27 ± 8.8 years) were included. Ambulatory 24-h blood pressure and central hemodynamic parameters were evaluated. Coronary artery calcium (CAC) score was assessed and carotid ultrasound was performed. Arterial stiffness was evaluated with carotid-femoral pulse wave velocity (cf-PWV). Patients were categorized in CVD risk groups based on 2019 European Society of Cardiology (ESC) guidelines, and the STENO T1D risk engine was used to estimate 10-year risk for CV events. This study aimed to evaluate arterial stiffness in T1D patients free from known CVD, and compare it to other CV risk evaluation tools used in T1D.Ĭross-sectional study in adults with a T1D duration of at least 10 years and without established CVD. However, its relation with other CV risk evaluation tools in T1D has not been elucidated yet. Arterial stiffness is a potential biomarker for cardiovascular disease (CVD) risk in patients with type 1 diabetes (T1D).
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